Biography

Sylvia LaCourse, MD, MPH is an Associate Professor at the University of Washington, Seattle, United States. Her research focuses on improved tuberculosis prevention, screening, and detection with a focus on people with HIV, including pregnant people and children. She leads clinical cohorts of pregnant people and children evaluating diagnostics for latent and active TB infection as well as interventional studies evaluating TB prevention therapy including among HIV-exposed uninfected children and pregnant people with HIV. Active areas of research include evaluation of non-sputum based TB diagnostics as well as the role of pregnancy and HIV in TB susceptibility.

Expertise

TB Diagnostics
Public Health

Key Impacts

Safety of rifapentine-based TB prevention in pregnant women with HIV on dolutegravir: DOLPHIN-Moms trial

Among pregnant PWH on twice daily DTG-ART, those receiving 3HP had fewer adverse composite safety events than 1HP. High rates of treatment completion and viral suppression were observed with both regimens, supporting expanded TB prevention options in pregnancy.

Source: Conference 2024
M. tuberculosis exosome detection in peripheral blood for pediatric TB

Impact details available upon request.

Source: Conference 2024