Biography

  1. Miner MD, Hatherill M, Mave V, Gray GE, Nachman S, et al. Developing tuberculosis vaccines for people with HIV: consensus statements from an international expert panel. Lancet HIV. 2022 Nov;9(11):e791-e800. doi: 10.1016/S2352-3018(22)00255-7. Epub 2022 Oct 11. PMID: 36240834
  2. Graham SM, Ahmed T, Amanullah F, et al. Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an expert panel. J Infect Dis 2012 May 15;205 Suppl 2:S199-208. PMID:22448023. PMCID: PMC3334506

Expertise

TB Diagnostics
Public Health

Key Impacts

Examining the differences and similarities of three adverse event grading systems used in TB clinical trials

AE grading for TB therapeutics in clinical trials vary considerably across DAIDS, CTCAE, and MSF, particularly within hematologic, psychiatric, and hepatobiliary disorders. These inconsistencies may impact clinical decision-making, prematurely terminate active trials, and lead to improperly assigned warnings for new TB therapeutics.

Source: Conference 2024