Biography

Sasini Jayaweera is a doctoral candidate from Hokkaido University, Japan, who focuses on antibiotic resistance and zoonotic diseases. Her current research focuses on fluoroquinolone resistance and biofilms produced by Mycobacterium avium. Sasini's primary objective is to determine the molecular mechanism by which nontuberculous mycobacteria develop drug resistance. She accomplishes this by researching DNA gyrase mutations and the efficacy of novel fluoroquinolones such as DC159a and sitafloxacin. Sasini is committed to enhancing the management of infectious diseases for the benefit of both human and animal health.

Expertise

TB Diagnostics
Public Health

Key Impacts

Potent inhibition of wild-type and fluoroquinolone-resistant M.avium DNA gyrase by sitafloxacin and DC159a

The results indicate that DC159a and sitafloxacin have a strong inhibitory profile against M. avium DNA gyrase A, suggesting that they may be used as a promising treatment.

Source: Conference 2024