Biography
Dr Mohammad Khaja Mafij Uddin is a Scientist at icddr,b’s Mycobacteriology Laboratory. He holds a BSc and MSc in Biochemistry and Molecular Biology from the University of Dhaka and a PhD in Medical Science from Hamamatsu University School of Medicine, Japan. He has been working on TB and Leprosy research for over 15 years. He has improved TB diagnostics using molecular, microbiological, and immunological approaches by adopting advanced techniques. His current research includes next generation sequencing for drug resistant TB detection, Transmission dynamics of TB, pharmacogenomics of DR-TB, blood-based biomarkers for TB detection and treatment monitoring.
Key Impacts
GeneXpert-negative samples with rpoB amplicons reveal High NTM prevalence: A diagnostic opportunity
This study highlights the added utility of rpoB2 Ct values from the GeneXpert Ultra assay for screening NTMs in GeneXpert-negative cases, enhancing diagnostic efficiency without additional cost. The findings emphasize the need for confirmatory molecular and culture-based testing to accurately identify NTMs and guide appropriate treatment. Incorporating rpoB screening into routine GeneXpert workflows offers an improvement for NTM identification.
Source: Conference 2024
Evaluation of a fluorescence immunoassay-based IGRA for latent TB diagnosis: A simplified, cost-effective alternative
Ichroma IGRA-TB demonstrates strong agreement with the costlier and more complex QFT. It has excellent performance among TB contacts and individuals with prior TB episodes. However, agreement among active TB cases remains lower, mirroring findings for currently established IGRA assays. With lower infrastructure constraints, minimal training requirements and faster results, ichroma IGRA-TB represents a cost-effective LTBI diagnostic alternative for resource-limited settings.
Source: Conference 2024
Epidemiology of tuberculosis infection among general population in a selected district of Bangladesh
One in every seven individuals was found to have TBI, lower than anticipated in a TB-endemic country. Risk of TBI was higher among older adults, male and individuals with a history of TB, diabetes or hypertension. Our findings highlighted importance of implementing targeted screening and prevention strategies among high-risk groups.
Source: Conference 2024