Biography
Dr. Dupnik is an Infectious Diseases physician-scientist who does translational research on the human immune response to mycobacterial pathogens, including in people who have both HIV and TB. Her current research focus is on the impact of TB on the establishment and persistence of the HIV reservoir in circulating CD4+ T cells.
Key Impacts
People living with HIV have increased plasmacytoid dendritic cells and systemic inflammation if they have history of pulmonary TB
A proinflammatory milieu and immune cell gene expression mediated by TNF persist in people living with HIV even years after TB. If the differences are preexisting risk factors or establish during the natural history of HIV and TB is still to be determined.
Source: Conference 2024