Biography
Jose Calderin is a PhD candidate in Pharmacometrics at the University of Cape Town. He holds a Bachelor's degree in Pharmaceutical Sciences from the University of Havana. His research focuses on population pharmacokinetic and pharmacodynamic modeling of anti-tuberculosis drugs, with a particular interest in optimizing treatment for tuberculous meningitis. Jose is passionate about applying model-informed drug development to improve therapies for infectious diseases and is actively involved in international pharmacometrics collaborations.
Key Impacts
Cerebrospinal fluid penetration of pyrazinamide, levofloxacin and linezolid in people with pulmonary TB
Pyrazinamide, levofloxacin, and linezolid CSF concentrations approached or exceeded their respective plasma fu, suggesting good CSF penetration and supporting further clinical evaluation in TBM. The CSF penetration observed in this study aligns with previous reports, including TBM cohorts, demonstrating that applying this methodology in small non-TBM cohorts can provide useful CSF drug penetration assessments for CNS infections.
Source: Conference 2024