Biography

Johanna Eggeling is a pediatric medical resident and researcher with a focus on tuberculosis immunology. Her work investigates immune cell phenotypes present before or during the early phases of TB treatment, aiming to identify biomarkers for diagnosis, treatment response, or disease progression. Combining clinical experience with translational research, she strives to bridge the gap between immunological insights and patient care. Passionate about improving outcomes in infectious diseases, especially among vulnerable pediatric populations, Johanna integrates clinical knowledge with a strong interest in host-pathogen interactions to help shape future diagnostics and personalized therapeutic strategies in TB management.

Expertise

TB Diagnostics
Public Health

Key Impacts

Multiparameter flow cytometry and machine learning identify a predictive blood-based immune signature for tuberculosis diagnosis and treatment monitoring

These findings suggest that cell populations associated with PD-L1-mediated immune exhaustion (neutrophils, CD4+ lymphocytes), early cytotoxic mycobacterial control (CD56+ Vd2+ gd T cells, CD56+ bright NK cells), and a Th1 immune response (CCR4-CXCR3+) define a comprehensive immunological signature varying with disease and treatment stages. This integrated signature represents a promising diagnostic and monitoring tool, warranting validation in larger and more diverse cohorts.

Source: Conference 2024