Biography
Infectious Disease Physician graduated at the Federal University of Paraná. PhD in Tropical and Infectious Diseases at the State University of Amazonas / Heitor Vieira Dourado Tropical Medicine Foundation. Currently an infectious disease physician at the State of Paraná Tuberculosis and HIV program; head of State Outclinic for DR-TB; member of Brazilian National Board for DR-TB; Dean of Faculdades Pequeno Príncipe School of Medicine and coordinator of the Multidrug-Resistant Tuberculosis area of the Brazilian Tuberculosis Research Network (REDE-TB).
Key Impacts
Is rifampin as part of fixed-dose combination tablet optimal for people in the with TB? A population pharmacokinetic study
Compared to outpatients, ICU patients displayed significantly different pharmacokinetics for an oral fixed-dose combination administration of rifampin. Total bilirubin and total body weight were important covariates influencing pharmacokinetic parameters.
Source: Conference 2024
Could first-line anti-TB drugs in fixed-dose combination tablets be administered through a nasogastric tube? A pharmaceutical technology assay
Key factors minimizing losses during FDC tablets containing RHZE include tablet fragmentation and pulverization prior to a 5-minute dilution period; utilization of 8 FR (100cm) and 10 FR (120cm) NGT. Bioavailability was not evaluated.
Source: Conference 2024