Biography

Christina Yoon, MD, MPH, MAS is an Associate Professor with the Division of Pulmonary & Critical Care Medicine at the University of California San Francisco. Her research is focused on improving active case-finding and TB prevention activities through the identification and evaluation of more accurate and/or efficient TB diagnostics. She has been studying novel TB screening tools, including CRP, for more than 10 years and led the TB SCRIPT trial whose objective was to evaluate the impact of CRP-based TB screening on important clinical outcomes of outpatient adults with HIV in Uganda.

Expertise

TB Diagnostics
Public Health

Key Impacts

A randomised-controlled trial comparing C-reactive protein- to symptom-based TB screening of people with HIV in Uganda: Primary 24-month effectiveness results

Among ART-naïve PWH, CRP-based TB screening did not reduce 2-year TB incidence and death compared to symptom screening. CRP was, however, able to detect a similar proportion with prevalent TB, while enabling twice as many PWH to initiate 3HP. These results support scale-up of CRP-based screening among ART-naïve PWH.

Source: Conference 2024