The tuberculosis-associated microenvironment promotes HIV-1 persistence by impairing CD8+ T cell-med
Gabriel Duette and colleagues report new findings on tuberculosis.
coinfection. These findings indicate that the TB-associated microenvironment promotes the persistence of cells infected with replication-competent HIV-1 by creating a niche of reduced antiviral immune pressure, potentially contributing to the worsened clinical outcomes observed in PLWH and TB.
Public Health Impact
This research may advance tuberculosis prevention and treatment. Further peer review will determine clinical relevance.
tuberculosis
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Author: Simon Cronin