Mycobacterium tuberculosis growth arrest on propionate at acidic pH is suppressed by mutations in ph
Robert B. Abramovitch and colleagues report new findings on tuberculosis.
mutant has enhanced sensitivity to pyrazinamide. Together, these findings support that propionate-driven growth arrest at acidic pH is caused by metabolic remodeling that is regulated by PhoPR and is associated with pyrazinamide sensitivity.
Public Health Impact
This research may advance tuberculosis prevention and treatment. Further peer review will determine clinical relevance.
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Author: Heather Murdoch